Damon and Carlton talk to TV Guide about Season 6

TVGuide.com: With the final season of Lost approaching, what are you feeling?
Carlton Cuse: I think we're doing something new in this final season narratively, so we have that combination of fear and giddiness. The fear is, oh, what if people don't like it, what if the audience doesn't like what we're doing? The giddiness is, like, we always feel like we have to be bold with our show and if it works, and if people like it as much as we do, we feel like the final season will be a success. When there's a draw though, we stand by our decisions. We're not playing it safe in the final season.
Damon Lindelof: I think at this point, the nervousness is more based on how we're so deep into this season, that by the time the audience sees it, we're committed to our path. It's been like that ever since we started premiering in January and February. It's like it's too late to turn back now. We're feeling very confident about executing what our plan was, and that's all you can ever do.

TVGuide.com: What do you say to fans with such high expectations for your last season?
Cuse: I think it's like anything in life. I think that you have to have realistic expectations. We're going to do our best version of the show, but there's still going to be some mystery and magic and intentionally ambiguous things that emerge at the end of the show. We're going to answer questions, but at the same time, we're going to tell the story the way we want to tell it. We feel like, all we can do is make the version of the show that makes Damon and I happy. If we do that, hopefully enough people will like it.
Lindelof: Ditto.

Source: Full Interview @ TV Guide