There's no place like home, but you can't go home again. That was already laid out in the monomyth structuring much of Lost's subtext, Joseph Campbell's The Hero With a Thousand Faces. The quickest way to show this might be:
A person leaves home to take care of some business. The person eventually crosses a threshold that divides the homeland from some other land.
There's a whole bunch of trials, temptations and dangers to be faced. If the person can successfully navigate those trials, the person's consciousness is changed. If the person doesn't successfully navigate the trials, well... (see Ben not being allowed back on the island)
After finally taking care of said business, the person eventually gets back home, but the person really isn't the same person as before because of the change in consciousness — the person is more like person2; same memories, same general identity, but a changed outlook that makes persona experience home in a different way. Person2 may even have a hard time relating to the homefolk because person2 can't express what it is she or he experienced out beyond the threshold.
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